The Plane of Sky is generally a raid zone only. Islands are inhabited by aggressive creatures and powerful bosses which require multiple groups to slay. All aggressive creatures do not see through invisibility, but movement is still restricted by the system of keys. Do not plan on entering this zone without seasoned help and/or a guild of allies.

Islands 2, 5 and 6 have initially aggressive creatures. Island 4 creatures become aggressive after one of them is killed, but have very short aggro radiuses.

Falling off an island will result in the player zoning out to East Freeport and landing in the bay off the dock. When this happens, they lose all their keys. If the player was AFK for some reason they will likely drown. A number of NPCs have Gravity Flux and forms of Knockback.

Boss NPCs and some others have the deathtouch (a.k.a. DT, Cazic Touch) ability with a 30 second cooldown. Bring lots of tanks.

Most of the loot from Plane of Sky quests are quite excellent for the Kunark era. All melee classes can quickly attain a 21% haste belt and eventually earn a 41% belt. There are also numerous useful clicky items for caster classes, such as the Vermilion Sky Ring for Shamans, the Duennan Shielding Ring for Magicians, and the Necklace of Resolution for Clerics. Magicians, Monks, Rangers, and Paladins will also find they must visit Plane of Sky for their epic quests. For these reasons, most casual raiding guilds will raid Plane of Sky once a week, and defeating every boss in Plane of Sky is considered a major milestone in a guild's rise to fame.

The Plane of Sky, like the Plane of Hate, is only accessible through the Wizard's spell Alter Plane: Sky, which requires Cloudy Stone of Veeshan for each cast. Upon entering, all buffs and debuffs are stripped from the characters. No form of teleport spell or ability will work within Plane of Sky, except for Alter Plane: Sky (which allows a group to return to island 1 with their keys). There are only two ways to leave, jumping or falling off an island, or death. After falling, a character will have all of his keys from Plane of Sky destroyed, and land in the ocean of East Freeport, east of the docks (swim directly west to get back to land, the docks should come into view quickly).